Biomedica Gruppe公司

骨代谢

心血管疾病

氧化应激

Osteoprotegerin

BNP Fragment*

MDA-oxLDL*

Free soluble Rankl

proANP

Peroxides

Dickkopf-1*

NT-proCNP

Autoantibodies against oxLDL

Sclerostin*

Big Endothelin

Cathepsin K*

Endothelin

Endostatin*

骨质酥松症、关节炎、骨代谢紊乱、肿瘤诱导的骨病

冠状动脉疾病、shen病、癌症

冠状动脉疾病、shen病、动脉硬化

骨代谢

应用

Osteoprotegerin （OPG）

心血管疾病评价的标记物

Free soluble Rankl (sRankl)

可控制孕酮水平变化导致的乳腺癌及抑制骨肿瘤细胞的进一步恶化。

Dickkopf-1(DKK-1)

减轻病人对骨髓瘤治疗的MM应答

Sclerostin

Sclerostin 抗体治疗，促进骨质形成。

Cathepsin K

心血管疾病

应用

BNP Fragment（8-29）

心血管疾病预后治疗检测的标记物

proANP（1-98）

抗肿瘤治疗的新靶点，可预测慢性心衰竭的患者的生存率。

NT-proCNP

可预测创伤引起的败血症发病率

Big Endothelin（1-38）

ET-A受体拮抗剂，用于改善冠脉内皮功能。

ET-B 受体，肿瘤免疫治疗的靶点

Endothelin（1-21）

Endostatin

内源性的血管生成抑制剂，是慢性shen脏病人微血管检测的可能的标记物

氧化应激

应用

MDA-oxLDL（MDA-oxLDL）

与代谢综合征和冠心病风险检测相关，是急性心肌梗死的影响因子。

Autoantibodies against oxLDL(oLAB)

评价药物对氧化低密度脂蛋白自身抗体产生的相关效应。

Peroxides

骨代谢标记物

在绝经妇女、骨固定引起的骨质流失患者、多重骨髓瘤患者Sclerostin水平显著升高。经甲状旁腺素（PTH）和雌性激素持续治疗后，血清Sclerostin水平降低。随着Sclerostin和DKK-1中和抗体的开发研究，有望对于骨代谢疾病治疗，获得新进展。

Sclerostin ELISA Kit (BI-20492)

检测方法

夹心ELISA，HRP/TMB显色系统

样本

血清、血浆

样本量

20ul/test，12 x8 test

检测范围

0-240pmol/L

灵敏度

2.6pmol/L

孵育时间

过夜/1h/30min

DKK-1和Sclerostins是wnt信号通路的有效的抑制剂，且在成骨细胞的分化过程中发挥重要作用。研究表明，骨形成减少、多发性骨髓瘤或由乳腺癌、前列腺癌、肺癌或关节炎引起的骨转移，都可导致DKK-1水平升高，

Dickkopf-1 ELISA kit (BI-20413)

检测方法

夹心ELISA，HRP/TMB 显色系统

样本

血清、细胞培养上清

样本量

20ul/test，12 x8 test

检测范围

0-160pmol/l

灵敏度

1.7pmol/L

孵育时间

2h/1h/30min

sRankl 是（NF）-KB配体的可溶性受体激活因子，是成熟破骨细胞形成的主要刺激因子，对于破骨细胞的存活具有重要作用。Rankl 激活位于成骨细胞及树突细胞其特异性受体Rank。

sRankl ELISA kit (BI-20452)

检测方法

夹心ELISA，检测系统：AP/ NADPH

样本

血清、血浆、细胞培养上清

样本量

100ul/test，12 x8 test

检测范围

0-2pmol/L

灵敏度

0.02pmol/L

孵育时间

过夜/1h/30min

OPG是Rankl的可溶性分泌受体，可抑制破骨细胞的发育。

Osteoprotegerin(OPG) ELISA kit (BI-20403)

检测方法

夹心ELISA，检测系统：HRP/TMB

样本

血清、血浆

样本量

20ul/test，12 x8 test

检测范围

0-20pmol/L

灵敏度

0.07 pmol/L

孵育时间

3h/1h/30min

Cathepsin K 是破骨细胞活化、重吸收中大量表达的合成蛋白。Cathepsin K含量的升高，反映了sRankl 激活破骨细胞的能力。

Cathepsin K ELSIA kit (BI-20432)

检测方法

夹心ELISA，检测系统：HRP/TMB

样本

血清、细胞培养上清

样本量

50ul/test，12 x8 test

检测范围

0-300pmol/l

灵敏度

1.1pmol/L

孵育时间

过夜/30min

参考文献

试验设计

结论

Association of sclerostin levels with the severity of aortic valve calcification. Koos R et al., JACC ; 2011; 57, 14

心脏主动脉瓣硬化患者

样本：115例

与正常人群相比心脏主动脉瓣硬化（AVC）患者，sclerostin水平显著升高。AVC疾病的严重程度与sclerostin血清水平相关。

Sclerostin and Dickkopf-1 in Renal Osteodystrophy. Cejka D et al., Clin J Am Soc  Nephrol; 2011; 6: 877-882

慢性shen脏病患者（CKD-5D）

样本：60例

针对高转换性骨代谢的CKD-5D病人除了检测IPTH外，还可检测Sclerostin作为评价指标。

Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemo-dialysis patients. Cejka D et al.,  Nephrol DiaTransplant; 2012; 27: 226-230

血透患者

样本：76例

对照样本：45例

血透患者的sclerostin水平，显著高于对照样本。骨密度（BMD）与血清sclerostin水平呈正相关。

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes. Gennari L et al., J Clin Endo Metab; 2012; 97: 1737-1744

II型糖尿病患者（DM2）：40例

I型糖尿病患者（DM1）：43例

对照样本：83人

研究表明，DM2患者sclerostin水平升高。此外，由PTH 抑制转录sclerostin可能在DM1和DM2病人减弱。

Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relation-ship with bone density and arterial stiffness. Thambiah S et al., Calcif Tissue Int; 2012; 90(6): 473-480

慢性shen脏疾病（CKD）3B期患者32例

慢性shen脏疾病（CKD）4期患者：45例

Sclerostin水平与年龄成正相关。男性Sclerostin水平要高于女性。shen小球滤过率（GFR）与Sclerostin水平呈负相关。骨密度（BMD）与血清sclerostin水平呈正相关。Wnt 信号通路可能在代谢紊乱疾病中发挥重要作用。

2013 ISN 研讨会会议论文（骨病与shen病）

试验设计

结论

Bone density and arterial stiffness are related to circulating sclerostin and Dickkopf-1 (DKK1) in pre-dialysis chronic kidney disease (CKD) patients. Goldsmith D et al.,  Poster # 15

血透前患者：

CKD 3B期和4期患者：77例

该研究为：Wnt 信号通路抑制剂（Sclerostin 及DKK-1）在确定骨骼和血管功能及慢性shen脏病人（CKD）结构中发挥重要的作用，提供有力证据。

Circulating sclerostin levels and vascular calcification in chronic kidney disease: A

complex relationship. Claes KJ et al.,Poster # 91

无机代谢纵向研究：154例

AC患者表达高水平的sclerostin。反之，sclerostin较低。后续的临床和实验研究需进一步阐明sclerostin是否在保护血管钙化中起到重要作用。

Sclerostin and DKK-1 levels in pre-dialysis CKD patients. Behts G et al.;  Poster # 89

观测性研究：

149病人（慢性shen病患者CKD 1-5期，男性：81例，60±16岁，22位糖尿病患者）

随着shen病严重程度，sclerostin（非DKK-1）水平升高。

Low PTH and high circulating sclerostin levels are independently associated with low bone specific alkaline phosphatase levels in hemodialysis patients. Viaene L et al., Poster # 90

血透病人：100例

Sclerostin水平的升高是糖尿病患者、shen功能不全（RRF）、急性胰腺炎(BSAP)患者的独立的风险因素。Sclerostin水平的高表达及PTH 的低表达与BSAP相关，反映了低水平的骨质形成。

*作者及参考文献

疾病

研究群体/试验设计

主要结论

Sclerostin: another bone-related protein related to all-cause mortality in haem dialysis? Viaene L et al., Nephrol Dial Transplant, 2013; 10.1093/ndt/gft039

 shen病

血透患者（观察随后637天个体的生存率），100例

血透患者Sclerostin水平的升高与提高生存率相关。

The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD. Pelletier S et al., Clin J Am Soc Nephrol, 2013; 8: 819-823

慢性shen病患者（CKD）：90例

在CKD III 期：Sclerostin水平开始升高。

Sclerostin and DKK-1 levels in pre-dialyisis CKD patients. Behets G et al., Nephrol Dial Transplant, 2012; 27: ii36-ii37

慢性shen病患者（横向观察性研究）：149例

随着shen病严重程度，sclerostin（非DKK-1）水平升高。

Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Cejka D et al., Nephrol Dial Trans-plant, 2012; 27: 226-230

血透患者（横向研究）：76例

血透患者的sclerostin水平，显著高于对照样本。

Sclerostin Levels Associated with Inhibition of the Wnt/β-Catenin Signaling and Reduced Bone Turnover in Type 2 Diabetes Mellitus. Gaudio A et al., J Clin Endocrinol Metab, 2012; 97: 3744–3750

糖尿病

绝经妇女II型糖尿病患者（横向研究）：40例

与之前研究结果一致，II型糖尿病患者sclerostin水平高于对照样本及骨转换标记物水平低于对照样本。

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes.

Gennari L et al., J Clin Endo Metab, 2012; 97: 1737-1744

I型和II型糖尿病患者（横向研究）

DM1：43例   DM2：40例

研究表明：II型糖尿病患者sclerostin水平升高。

Association of Sclerostin levels with the severity of aortic valve calcification. Koos et al., JACC, 2011; 57, 14

心脏主动脉瓣硬化

主动脉瓣患者（横向研究）：115例

与正常健康对照样本群体比较，AVC患者sclerostin水平升高。

Serum Sclerostin levels are associated with aortic valve calcification in prevalent ha-emodialysis patients. Türkvatan A et al., Nephrol Dial Transplant, 2013; 28: i19–i21

血透患者：101例

AVC患者sclerostin血清水平显著高于未钙化的AVC患者相比，。

Circulating Sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness. Thambiah S et al., Calcif Tissue Int, 2012; 90(6): 473-480

动脉硬化

慢性shen病患者CKD 3BQ期和4期：77例

shen小球滤过率（GFR）与Sclerostin水平呈负相关。Wnt 信号通路可能在代谢紊乱疾病中发挥重要作用。

检测特点

BI-20413

BI-20412

孵育时间

2h/1h/30min

孵育过夜

样品处理

直接测定

需要1:4稀释

标准品范围

0-160pmol/L

0-50pmol/L

1

Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin

and Dickkopf-1 Levels of Naive Postmenopausal Women With Low Bone Mass: A

Randomized, Head-to-Head Clinical Trial. Athanasios D. Anastasilakis, et al.

J. Clin. Endocrinol. Metab., Aug 2013; 98: 3206 - 3212.

2

Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.

3

Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.

4

High dickkopf-1 levels in sera and leukocytes from children with 21-

hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554.

5

Sclerostin and DKK1 in postmenopausal osteoporosis treated with denosumab. D Gatti,et al. J Bone Miner Res, Nov 2012; 27(11): 2259-63. 

6

Sclerostin Levels Associated with Inhibition of the Wnt/β-Catenin Signaling and Reduced Bone Turnover in Type 2 Diabetes Mellitus. Agostino Gaudio,et al. J. Clin. Endocrinol. Metab., Oct 2012; 97: 3744 - 3750.

7

Serum Osteoprotegerin, RANKL, and Dkk-1 Levels in Adults with Langerhans

Cell Histiocytosis. Polyzois Makras,et al. J. Clin. Endocrinol. Metab., Apr 2012; 97: E618 - E621

8

High level of functional dickkopf-1 predicts protection from syndesmophyte

formation in patients with ankylosing spondylitis. Gisela Ruiz Heiland,et al. Ann Rheum Dis, Apr 2012; 71: 572 - 574. 

9

Assessment of circulating Dickkopf-1 with a new two-site immunoassay in

healthy subjects and women with breast cancer and bone metastases. N Voorzanger-Rousselot, et al. Calcif Tissue Int, May 1, 2009; 84(5): 348-354

10

Circulating Dickkopf-1 and Radiological Progression in Patients with Early

Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008.

11

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss. Agostino Gaudio,et al. J. Clin. Endocrinol. Metab., May 2010; 95: 2248 - 2253.

12

High Serum Sclerostin Correlates with Advanced Stage, Increased Bone

Resorption, Reduced Osteoblast Function, and Poor Survival in Newly-Diagnosed Patients with Multiple Myeloma. Evangelos Terpos,et al. Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 425.

13

The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKL

in Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009 

14

Glucocorticoids Attenuate the Stimulatory Effect on Bone Formation by

Bortezomib. Thomas Lund,et al. Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 5183. 

参考文献

试验设计

结论

Elevated plasma levels of endostatin are associated with chronic kidney disease. J Chen, LL Hamm, et al.Am J Nephrol, Jan 2012; 35(4): 335-340

CKD患者：201例

对照群体：201例

血浆Endostain的升高，与CKD患者高度相关。进一步研究及临床实验已批准验证Endostain与CKD发病风险之间的关系及研究针对Endostain的新的干预措施，以减少CKD的发病风险。

Early-onset coronary artery disease after pediatric kidney transplantation: implicatingthe angiogenesi inhibitor, endostatin. CW Iqbal,et al. Am Surg, Jun 2011; 77(6): 731-735

接受shen移植者：12例

接受肝移植者：8例

与肝移植者及健康对照个体相比，shen移植者Endostain水平升高。Endostain在shen移植后引起的动脉硬化疾病中发挥重要作用，且Endostain可能作为动脉硬化疾病检测的生物标记物。

Immobilized kidney 28-kDa endostatin-related (KES28kDa) fragment

promotes endothelial cell survival.MH Bellini, et al.

Am J Nephrol, Jan 2010; 31(3): 255-261

可溶性和固定化的Endostatin 对细胞活性影响。

研究表明：由急性shen损伤（AKI）引起的局部合成28KD相关的Endostain片段，对于内皮细胞的存活，发挥重要作用。

Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Neel R. Sodha, et al.Am J Physiol Heart Circ Physiol, Feb 2009; 296: H428-H434

经动脉搭桥术手术病人的心肌组织

（非糖尿病例：11例 ，II型糖尿病：10例）

研究表明：在促血管新生治疗中，Endostain是潜在的治疗靶点，且糖尿病患者可见血管损伤。

A defective angiogenesis in chronic kidney disease.N Futrakul,et al. Jan 2008; 30(2): 215-217

通过研究血管生成因子、Endostain、VEGF、抗血管生成因子之间的平衡，来反映血管损伤程度。

慢性shen病(CKD)患者Endostain及CEC非正常升高，而VEGF表现为缺乏。

1

Infliximab Treatment Increases Left Ventricular Ejection Fraction in Patients with Rheumatoid Arthritis: Assessment of Heart Function by Echocardiography, Endothelin 1, Interleukin 6, and NT-pro Brain Natriuretic Peptide. PRZEMYSLAW J,et al. J Rheumatol, Apr 2012; 39: 701 - 706.

2

Left Ventricular Function Impairment in Patients With Normal-Weight Obesity:

Contribution of Abdominal Fat Deposition, Profibrotic State, Reduced Insulin

Sensitivity, and Proinflammatory Activation. Wojciech Kosmala,et al. Circ Cardiovasc Imaging, May 2012; 5: 349 - 356.

3

Prognostic value of left atrial expansion index and exercise-induced change in atrial natriuretic peptide as long-term predictors of atrial fibrillation recurrence..Malini Govindan,et al. Europace, Sep 2012; 14: 1302 - 1310.

4

Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl

oxidase? Begoña López,et al. Cardiovasc Res, Jul 2013; 99: 111 - 120. 

5

High-sensitivity troponin assay improves prediction of cardiovascular risk in

patients with cerebral ischaemia. Raoul Stahrenberg,et al. J. Neurol. Neurosurg. Psychiatry, May 2013; 84: 479 - 487.

6

Translational phases of evidence in a prognostic biomarker: a systematic review and meta-analysis of natriuretic peptides and the prognosis of stable coronary disease. Shailen Sutaria,et al. Heart, Apr 2012; 98: 615 - 622. 

7

Prognostic impact of body mass index in patients undergoing coronary artery

bypass surgery. Shih-Hsien Sung,et al. Heart, Apr 2011; 97: 648 - 654.

8

Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus

scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infants. Afif F EL-Khuffash,et al. Arch. Dis. Child. Fetal Neonatal Ed., Mar 2011; 96: F133 - F137. 

9

Multidimensional assessment of older people with asthma and COPD: clinical

management and health status. Vanessa M. McDonald,et al. Age Ageing, Jan 2011; 40: 42 – 49

10

Diagnostic value of NT-proBNP in identifying aortic stenosis patients with heart failure. C Wu,et al. Zhonghua Xin Xue Guan Bing Za Zhi, Jul 2010; 38(7): 579-83.

11

Pulmonary arterial hypertension in rheumatic mitral stenosis: does it affect right

ventricular function and outcome after mitral valve replacement? Shantanu Pande,et al. Interact CardioVasc Thorac Surg, Sep 2009; 9: 421 - 425

12

Pulmonary arterial hypertension in rheumatic mitral stenosis: does it affect right

ventricular function and outcome after mitral valve replacement? Shantanu Pande,et al. Interactive CardioVascular and Thoracic Surgery, Sep 2009; 9: 421 - 425.

13

Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular

function in patients with symptomatic heart failure. John K. Kjekshus,et al. Eur J Heart Fail, Aug 2009; 11: 771 – 778

14

Prevalence of Left Ventricular Diastolic Dysfunction in a General Population. Tatiana Kuznetsova,et al. Circ Heart Fail, Mar 2009; 2: 105 - 112.

1

Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones. Clerico A et al., Am J Physiol Heart Circ Physiol 2011; 301: H12-H20

2

Comparison of Pleural Fluid N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic-32 Peptide Levels. Long AC et al., Chest 2010; 137: 1369-1374

3

N-Terminal Pro-B-Type Natriuretic Peptide as an Indicator of Possible Cardiovascular Disease in Severely Obese Individuals: Comparison with Patients in Different Stages of Heart Failure. Hermann-Arnhof K et al., Cl inical Chemistry 2005; 51:138-143

4

Natriuretic Peptides: New Players in Energy Homeostasis.  Moro C and Smith RH, Diabetes 2009; 58: 27-26

5

Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide. Jarai R et al., Eur Heart J 2004; 26: 250-256

6

Natriuretic peptides: Markers or modulators of cardiac hypertrophy? Gardner DG, Trends Endocrinol Metab 2003; 14: 411-416

7

Neurohormonal risk stratification for sudden death and death owing to progressive heart failure in chronic heart failure. Berger R et al, Eur J Clin Invest 2005, 35, 24-31

8

Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity. Miyashita K et al., Diabetes 2009; 58: 2880-2892

9

Processing of Pro–B-Type Natriuretic Peptide: Furin and Corin as Candidate Convertases. Semenov AG et al., Clin Chem. 2010; 56:1166-1176

1

C4d deposition is associated with inferior kidney allograft outcome independ.of cellular rejection. Regele H. et al., Nephrol Dial Transplant. 2001, 16(10): 2058-2066.

2

Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury. Böhmig GA et al., J Am Soc Nephrol. 2002, 13(4): 1091-1099.

3

[C4d]FlowPRA screening—a specific assay for selective detection of complement-activating anti-HLA alloantibodies. Wahrmann M et al., Hum Immunol, 2005, 66(5): 526-534

4

Pivotal role of complement-fixing HLA alloantibodies in presensitized kidney allograft recipients. Wahrmann M et al., Am J Transplant, 2006, 6: 1033-1041.

5

In vitro detection of C4d-fixing HLA alloantibodies: associations with capillary C4d deposition in kidney allografts. Bar G et al., Am J Transplant, 2008, 8(1): 41-49

6

Antibodies, isotypes and complement in allograft rejection. Böhmig GA et al., Curr Opin Organ

Transplant, 2008, 13(4): 411-418

7

Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients. Bar G et al., Transpl Int. 2013; 26(2): 121-130.

8

Preformed complement-activating low-level donor-specific antibody predicts early antibody-mediated rejection in renal allografts. Lawrence C et al., Transplantation 2013 Jan 27; 95(2): 341-346.

9

Modified solid-phase alloantibody detection for improved crossmatch prediction. Wahrmann M et al., Hum Immunol. 2013 Jan; 74(1): 32-40.

类别

货号

名称

规格

骨代谢系列

BI-20492

Sclerostin (SOST) ELISA 

1 Kit

BI-20413 

DKK-1 ELISA 

1 Kit

BI-20432 

Cathepsin K ELISA Kit

1 Kit

BI-20403

OPG ELISA

1 Kit

BI-20452

sRANKL ELISA

1 Kit

心血管疾病

BI-20742 

Endostatin ELISA

1 Kit

BI-20082H

Big Endothelin-1 ELISA

1 Kit

BI-20052

Endothelin ELISA

1 Kit

BI-20872 

NT-proCNP ELISA

1 Kit

BI-20852W

BNP Fragment ELISA

1 Kit

SK-1204

NT-proBNP ELISA

1 Kit

BI-20892

proANP ELISA

1 Kit

动脉硬化

氧化应激

BI-20032

Anti-Oxidized LDL (oLAB) ELISA

1 Kit

BI-5007

OxyStat Assay (Peroxides)ELISA

1 Kit

BI-20022

MDA-oxLDL ELISA

1 Kit

传染病

BI-21032 

Borrelia lgG ELISA

1 Kit

BI-21042

Borrelia lgM ELISA

1 Kit

BI-3501 

Rheumatoid Factor Stripper

1 Kit

细胞增殖

BI-5000

EZ4U Cell Proliferation Assay

1 Kit

抗体

BI-RC4D

Polyclonal Anti-human C4d antibody

200ul

BI-RC4D-FITC

Polyclonal Anti-human C4d FITC Antibody

100 µl

BI-RC4D-PE

Polyclonal Anti-human C4d PE Antibody

50 µl